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Proefschrift

Insulin-like growth factor-1 and risk of late-onset Alzheimer's disease: findings from a family study.

  • van Exel E, Eikelenboom P, Comijs H, Deeg DJ, Stek M, Westendorp RG.

van Exel E, Eikelenboom P, Comijs H, Deeg DJ, Stek M, Westendorp RG.

Jaar: 2013

Samenvatting:

Insulin-like growth factor-1 (IGF-1), part of an evolutionary conserved signaling pathway in both mammalian and non-mammalian species, is inferred in neurodegenerative disorders including Alzheimer's disease (AD). A murine model for AD shows that reduced IGF-1 signaling prevents AD-like characteristics. However, variation in serum levels of IGF-1 and risk of AD in humans has yet to be determined.