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Proefschrift

Hypothalamic-pituitary-adrenal axis activity in older persons with and without a depressive disorder.

  • Rhebergen D, Korten NC, Penninx BW, Stek ML, van der Mast RC, Oude Voshaar R, Comijs HC.

Rhebergen D, Korten NC, Penninx BW, Stek ML, van der Mast RC, Oude Voshaar R, Comijs HC.

Jaar: 2014

Samenvatting:

Altered functioning of the hypothalamic-pituitary-adrenal axis (HPA-axis) has been associated with depression, but findings have been inconsistent. Among older depressed persons, both hyperactivity and hypo-activity of the HPA-axis were demonstrated. However, most studies were population-based studies, with single cortisol measurements, lacking insight into diurnal patterns of HPA-axis functioning. We aim to provide insight into functioning of the HPA-axis, assessed by various salivary cortisol samples, in depressed older adults and non-depressed controls.