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Proefschrift

BDNF serum levels are not related to cognitive functioning in older depressed patients and controls.

  • Dols A, Thesing CS, Bouckaert F, Voshaar RC, Comijs HC, Stek ML.

Dols A, Thesing CS, Bouckaert F, Voshaar RC, Comijs HC, Stek ML.

Jaar: 2014

Samenvatting:

Depression and cognitive decline are highly prevalent in older persons and both are associated with low serum brain derived neurotrophic factor (BDNF). Mutual pathways of depression and cognitive decline in older persons may explain the overlap in symptoms and low serum BDNF. We hypothesized that serum BDNF levels are lower in depressed elderly with poor cognitive performance (global or specifically in working memory, speed of information processing, and episodic memory) compared to depressed elderly without cognitive impairment or non-depressed controls.