Oudega ML, Dols A, Adelerhof I, Rozing M, Wattjes MP, Comijs HC, Barkhof F, Eikelenboom P, Stek ML, van Exel E. J. Affect Disord.
Depression and cognitive decline are highly prevalent and often coexisting, however, the association between depression and dementia remains unclear.
White matter hyperintensities (WMH), medial temporal lobe atrophy (MTA) and global cortical atrophy (GCA) are associated with depression, mild cognitive impairment and dementia; these structural abnormalities may therefore represent a common underlying mechanism of these diseases. We conducted a naturalistic prospective follow-up study in patients with severe geriatric depression who were formerly treated with ECT. The aim of the study was to investigate the effects of structural abnormalities in the brain on cognitive decline, dementia and survival.