Skip to content

Proefschrift

Contribution of white matter hyperintensities, medial temporal lobe atrophy and cortical atrophy on outcome, seven to twelve years after ECT in severely depressed geriatric patients.

  • Oudega ML, Dols A, Adelerhof I, Rozing M, Wattjes MP, Comijs HC, Barkhof F, Eikelenboom P, Stek ML, van Exel E. J. Affect Disord.

Oudega ML, Dols A, Adelerhof I, Rozing M, Wattjes MP, Comijs HC, Barkhof F, Eikelenboom P, Stek ML, van Exel E. J. Affect Disord.

Jaar: 2015

Samenvatting:

Depression and cognitive decline are highly prevalent and often coexisting, however, the association between depression and dementia remains unclear.
White matter hyperintensities (WMH), medial temporal lobe atrophy (MTA) and global cortical atrophy (GCA) are associated with depression, mild cognitive impairment and dementia; these structural abnormalities may therefore represent a common underlying mechanism of these diseases. We conducted a naturalistic prospective follow-up study in patients with severe geriatric depression who were formerly treated with ECT. The aim of the study was to investigate the effects of structural abnormalities in the brain on cognitive decline, dementia and survival.